DEFIENCY OF MICROELEMENTS IN CHILDREN AND BRONCHIAL HYPERREACTIVITY
Keywords:
hyperreactivity of the bronchi, microelementoses, atopic dermatitis, bronchial asthma.Abstract
The study shows pathogenetic mechanisms of formation of bronchial hyperreactivity associated with microelementosis. The study group consisted of 58 children with a combination of atopic dermatitis and bronchial asthma. Methods: inhalation-provocation tests with histamine and metacholine, atomic absorption spectrometry, x-ray fluorescence method. The state of hyperreactivity of the bronchi was accompanied by a deficit of essential microelements (69.6 %) with high sensitivity of the bronchi (PK20 metacholine, histamine-0.125-0.5 mg / ml), against the background of selenium and zinc deficiency (plasma content below 0.2 and 0.35 mg / l, respectively), reducing the speed parameters of the external respiratory function.
References
1. Koh Y. Y. Bronchial hyperresponsiveness in adolescents with long-term asthma remission : importance of a Family history of bronchial hyperresponsiveness / Y. Y. Koh, E. K. Kang, H. Kang // Chest. — 2003. — Vol. 124, N 3. — P. 819–825.
2. A mineral homeostasis and respiratory violations in case of bronchial asthma at children /
T. G. Reshetova [etc.] // Pulmonology of children’s age: problems and decisions, Iss. — Moscow-Ivanovo, 2002. — P. 140-142.
M. Anke, D. Meissner, C. F. Mils. — Dresden, 1993. — P. 890–891.
3. Richter M. Zinc status modulates bronchopulmonary eosinophil infiltration in a murine model of allergic inflammation / M. Richter, R. Bonneau, M. A. Girard // Chest. — 2003.
— Vol. 123 (3 Suppl). — P. 446.
4. Vural H. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma / H. Vural, K. Uzun, E. Uz // J. Trace Elem. Med. Biol. — 2000. — Vol. 14 (2). — P. 88–91.
5. Immunopharmacology of Pmicrocells / A. V. Kudrin [etc.]. — M.: Publishing house of KMK, 2000. — 537 P.
6. Rustembekova of S. A. Microelementosis and factors of environmental risk / S. A. Rustembekova, T. A. Baraboshkin. — M.: Логос, 2006. — 196 P.
7. Boulet L. P. Physiopathology of airway hyperresponsiveness / L. P. Boulet // Curr. Allergy Asthma Rep. — 2003. — Vol. 3, N 2. — P. 166–171.
8. Standartization of research tests for lung function / А. G. Chuchalin [and others]. — М. : Pulmonology, 1993. — P. 60–86.
9. Suh DI, Lee JK, Kim CK, Koh YY. Bronchial hyperresponsiveness to methacholine and adenosine 5'-monophosphate, and the presence and degree of atopy in young children with asthma. Clin Exp Allergy. 2011;41:338–34
10. Dong In Suh and Young Yull Koh Relationship Between Atopy and Bronchial Hyperresponsiveness. /Allergy,Asthma et Immunology research//, 2013—July 5(4), P 181-188
11. Molokova A.V., Pavlenko N.S.,Ishkova N.S. Microelementosis in children with hyperreactivity of bronchi / Journal of Siberian Medical Sciences // № 5 - 2014 y.P135-14
12. Nella Paramonova Observe or treat bronchial hyperreactivity in children? /European Respiratory Journal// 2014;44 P 4470
13. Hallstrand TS, Leuppi JD, Joos G, Hall GL, Carlsen KH, Kaminsky DA, Coates AL, Cockcroft DW, Culver BH, Diamant Z, Gauvreau GM, Horvath I, de Jongh FHC, Laube BL, Sterk PJ, Wanger J., American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur. Respir. J. 2018 Nov;52(5)
